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An imperfect reference test does not perfectly reflect the truth (ie, it can give false results). Study Selection Studies needed to provide enough data to measure salivary NAAT sensitivity and specificity compared with imperfect nasopharyngeal swab NAAT as a reference test. The final meta-analysis was performed on November 17, 2020. Objective To assess the diagnostic accuracy of saliva NAAT for COVID-19.ĭata Sources In this systematic review, a search of the MEDLINE and medRxiv databases was conducted on August 29, 2020, to find studies of diagnostic test accuracy. Saliva NAAT represents an attractive alternative, but its diagnostic performance is unclear. However, it requires trained personnel, limiting its availability. Importance Nasopharyngeal swab nucleic acid amplification testing (NAAT) is the noninvasive criterion standard for diagnosis of coronavirus disease 2019 (COVID-19). Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.
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Challenges in Clinical Electrocardiography.